Motor dysfunction influence on executive functioning in manifest and premanifest Huntington's disease.
Identifieur interne : 000515 ( Main/Exploration ); précédent : 000514; suivant : 000516Motor dysfunction influence on executive functioning in manifest and premanifest Huntington's disease.
Auteurs : Ellen P. Hart [Pays-Bas] ; Eve M. Dumas ; Anne Schoonderbeek ; Shalane C. Wolthuis ; Erik W. Van Zwet ; Raymund A C. RoosSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- complications : Huntington Disease.
- etiology : Motor Neuron Disease.
- physiology : Cognition, Executive Function.
- physiopathology : Huntington Disease, Motor Neuron Disease.
- Adult, Aged, Disease Progression, Female, Humans, Male, Middle Aged, Neuropsychological Tests.
Abstract
Motor disturbances can be present in both manifest and premanifest Huntington's disease (HD). We aimed to investigate the role of motor functioning on executive functioning to better understand the progression of cognitive dysfunction in HD. Forty patients with manifest HD, 21 patients with premanifest HD, and a group of 28 controls were tested twice with a 1-year interval. For the Symbol Digit Modalities Test and the Figure Fluency Test, extra conditions were designed to measure motor involvement. Subtraction of this motor score from the original test score resulted in isolation of the cognitive component. Groups were compared on motor, cognitive, and original test scores using multilevel regression analysis. Manifest patients had lower baseline scores of 0.53 standard deviations (SD) on the original Symbol Digit Modalities Test (P = 0.03) and 0.71 SD on the motor isolation part (P = 0.006), and they showed a deterioration of 0.47 SD over 1 year of follow-up on the original Symbol Digit Modalities Test (P = 0.001) compared with controls. Premanifest patients had lower baseline scores of 0.67 SD on the Symbol Digit Modalities motor part (P = 0.008) and deterioration of 0.48 SD on the original (P = 0.001) and cognitive isolation (P = 0.02) parts. Secondary analyses revealed that the premanifest deterioration resulted from the close-to-predicted-onset group. Motor disturbances have a negative influence on performance on the Symbol Digit Modalities Test. Isolation of the cognitive component of this test revealed cognitive deterioration in the premanifest group only, caused by deteriorating scores for patients who were close to their predicted clinical disease onset. The Figure Fluency Test did not prove sensitive to cognitive change.
DOI: 10.1002/mds.25806
PubMed: 24500841
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Motor dysfunction influence on executive functioning in manifest and premanifest Huntington's disease.</title><author><name sortKey="Hart, Ellen P" sort="Hart, Ellen P" uniqKey="Hart E" first="Ellen P" last="Hart">Ellen P. Hart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center Leiden</wicri:regionArea><wicri:noRegion>Leiden University Medical Center Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Dumas, Eve M" sort="Dumas, Eve M" uniqKey="Dumas E" first="Eve M" last="Dumas">Eve M. Dumas</name></author><author><name sortKey="Schoonderbeek, Anne" sort="Schoonderbeek, Anne" uniqKey="Schoonderbeek A" first="Anne" last="Schoonderbeek">Anne Schoonderbeek</name></author><author><name sortKey="Wolthuis, Shalane C" sort="Wolthuis, Shalane C" uniqKey="Wolthuis S" first="Shalane C" last="Wolthuis">Shalane C. Wolthuis</name></author><author><name sortKey="Van Zwet, Erik W" sort="Van Zwet, Erik W" uniqKey="Van Zwet E" first="Erik W" last="Van Zwet">Erik W. Van Zwet</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24500841</idno><idno type="pmid">24500841</idno><idno type="doi">10.1002/mds.25806</idno><idno type="wicri:Area/PubMed/Corpus">000589</idno><idno type="wicri:Area/PubMed/Curation">000589</idno><idno type="wicri:Area/PubMed/Checkpoint">000523</idno><idno type="wicri:Area/Ncbi/Merge">003F08</idno><idno type="wicri:Area/Ncbi/Curation">003F08</idno><idno type="wicri:Area/Ncbi/Checkpoint">003F08</idno><idno type="wicri:Area/Main/Merge">000515</idno><idno type="wicri:Area/Main/Curation">000515</idno><idno type="wicri:Area/Main/Exploration">000515</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Motor dysfunction influence on executive functioning in manifest and premanifest Huntington's disease.</title><author><name sortKey="Hart, Ellen P" sort="Hart, Ellen P" uniqKey="Hart E" first="Ellen P" last="Hart">Ellen P. Hart</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Leiden University Medical Center Leiden, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Leiden University Medical Center Leiden</wicri:regionArea><wicri:noRegion>Leiden University Medical Center Leiden</wicri:noRegion></affiliation></author><author><name sortKey="Dumas, Eve M" sort="Dumas, Eve M" uniqKey="Dumas E" first="Eve M" last="Dumas">Eve M. Dumas</name></author><author><name sortKey="Schoonderbeek, Anne" sort="Schoonderbeek, Anne" uniqKey="Schoonderbeek A" first="Anne" last="Schoonderbeek">Anne Schoonderbeek</name></author><author><name sortKey="Wolthuis, Shalane C" sort="Wolthuis, Shalane C" uniqKey="Wolthuis S" first="Shalane C" last="Wolthuis">Shalane C. Wolthuis</name></author><author><name sortKey="Van Zwet, Erik W" sort="Van Zwet, Erik W" uniqKey="Van Zwet E" first="Erik W" last="Van Zwet">Erik W. Van Zwet</name></author><author><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Cognition (physiology)</term><term>Disease Progression</term><term>Executive Function (physiology)</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (physiopathology)</term><term>Male</term><term>Middle Aged</term><term>Motor Neuron Disease (etiology)</term><term>Motor Neuron Disease (physiopathology)</term><term>Neuropsychological Tests</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Motor Neuron Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Executive Function</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Huntington Disease</term><term>Motor Neuron Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Motor disturbances can be present in both manifest and premanifest Huntington's disease (HD). We aimed to investigate the role of motor functioning on executive functioning to better understand the progression of cognitive dysfunction in HD. Forty patients with manifest HD, 21 patients with premanifest HD, and a group of 28 controls were tested twice with a 1-year interval. For the Symbol Digit Modalities Test and the Figure Fluency Test, extra conditions were designed to measure motor involvement. Subtraction of this motor score from the original test score resulted in isolation of the cognitive component. Groups were compared on motor, cognitive, and original test scores using multilevel regression analysis. Manifest patients had lower baseline scores of 0.53 standard deviations (SD) on the original Symbol Digit Modalities Test (P = 0.03) and 0.71 SD on the motor isolation part (P = 0.006), and they showed a deterioration of 0.47 SD over 1 year of follow-up on the original Symbol Digit Modalities Test (P = 0.001) compared with controls. Premanifest patients had lower baseline scores of 0.67 SD on the Symbol Digit Modalities motor part (P = 0.008) and deterioration of 0.48 SD on the original (P = 0.001) and cognitive isolation (P = 0.02) parts. Secondary analyses revealed that the premanifest deterioration resulted from the close-to-predicted-onset group. Motor disturbances have a negative influence on performance on the Symbol Digit Modalities Test. Isolation of the cognitive component of this test revealed cognitive deterioration in the premanifest group only, caused by deteriorating scores for patients who were close to their predicted clinical disease onset. The Figure Fluency Test did not prove sensitive to cognitive change.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Dumas, Eve M" sort="Dumas, Eve M" uniqKey="Dumas E" first="Eve M" last="Dumas">Eve M. Dumas</name><name sortKey="Roos, Raymund A C" sort="Roos, Raymund A C" uniqKey="Roos R" first="Raymund A C" last="Roos">Raymund A C. Roos</name><name sortKey="Schoonderbeek, Anne" sort="Schoonderbeek, Anne" uniqKey="Schoonderbeek A" first="Anne" last="Schoonderbeek">Anne Schoonderbeek</name><name sortKey="Van Zwet, Erik W" sort="Van Zwet, Erik W" uniqKey="Van Zwet E" first="Erik W" last="Van Zwet">Erik W. Van Zwet</name><name sortKey="Wolthuis, Shalane C" sort="Wolthuis, Shalane C" uniqKey="Wolthuis S" first="Shalane C" last="Wolthuis">Shalane C. Wolthuis</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Hart, Ellen P" sort="Hart, Ellen P" uniqKey="Hart E" first="Ellen P" last="Hart">Ellen P. Hart</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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